Applied physicists at the California Institute of Technology have devised a method that uses microscope optics to detect biomolecules. It has been proved that this method can effectively detect a signaling protein that shows the function of the immune system, namely cytokine. This method has broad medical application prospects, not only for the timely diagnosis of cancer and other diseases, but also for basic biological research.
According to Kerry Wahala, a professor of information technology and a professor of applied physics, his laboratory had previously invented an "ultra-high Q miniature ring core resonator". The new detection technology is based on this invention. core. This is a ring-shaped glass device, whose width is thinner than human hair, and it can continue to emit light very effectively. Wahala explained: "With this feature, the sensitivity of the detector can reach the level of a single molecule, although this is a bit incredible." He emphasized that the original idea was to detect the optical caused by molecules attached to the ring device reaction. "With the deepening of research, we can observe single-molecule detection events, and it is much easier than the original design." This is really a pleasant surprise. The reason is that when the molecules store light inside the miniature ring core resonator The heat will be generated when the interaction occurs, and the device can accurately record the heat. Wahala explained: "This thermo-optical reaction has increased the sensitivity by a million times." Andrea Armani worked in Wahala's laboratory, and she developed the device as her thesis research. In part, she emphasized that the device is not only extremely sensitive, but also programmable, by coating its surface with materials that can react with special biomolecules.
"Whether the molecule observed by this device is a growth factor or a chemical molecule similar to TNT will be determined by the surface treatment of the glass micro-ring core." Fortunately, the biological and chemical communities have developed a protein and glass Surface-to-surface technology, which is very effective because most microscope slides are made of glass. What we need to do is use this technique to prepare our structure. Wahhara emphasized that "combining the sensitivity of a single molecule with a programmable detection method means that there is no need to label the target molecule, which has no precedent in the past, and it will enable new test and measurement methods."
Scott Fraser, a professor of biology and bioengineering who is a collaborator of the project, further explained: "The technology will be widely used in biological experiments, medical experiments, and even medical fields. Its advantage lies in its ability to detect There are very few molecules, and there is no need to label the target molecule. With this sensitivity, it can even be used to study the growth factor released by a single cell in real time. â€Fraser added:“ This is the only one with this An essential sensor for sensitivity and speed. "
This type of experiment is very important for monitoring how the environment changes, such as monitoring pH or temperature, which can affect the behavior of a cell. At present, millions of cells must be used to complete this type of experiment, which often obscures the results, because it is like trying to pick a single voice from the choir. "
In the online edition of Science Express, the team reported that it has successfully detected a series of different molecules, including an immune response signaling protein, interleukin-2 (IL-2). In order to detect IL-2, the corresponding molecule coated on the device is a special antibody that can recognize IL-2. This surface treatment allows the detector surface to be combined with IL-2, while at the same time, the thermo-optic mechanism provides the single-molecule-level sensitivity necessary to detect IL-2, even in serum.
The most exciting thing is that the device can obtain single molecule observations in real time without labeling. The reason is that it can detect almost any kind of biomolecule according to the procedure. It is a universal detector. Because of this, it will open its doors to all new experiments.
Field fence also named as grassland
fence, wildlife mesh fence, deer mesh fence, cattle mesh fence, is a kind of mesh fence used for animals like cattle, goat, deer, pig, park and public areas. They are made
by automated machine, offer high strength and tensile strength, provide
safety fencing against fierce striking of cattle,horse or goats.
Features
Ÿ Materials: carbon steel wire.
Ÿ Surface Treatment: Electro galvanized, Hot dipped galvanized.
Ÿ Type: Hinge Joint Knot, Fixed Knot.
Benefits
Ÿ Extremely strong and durable
Ÿ Long lasting and rust resistant
Ÿ Woven construction allows fence to conform to uneven terrain
Ÿ Small mesh openings discourage animals from putting heads through
Electro Galvanized Wildlife Mesh Fence,Hot Dipped Galvanized Deer Fence Mesh, Galvanized Cattle Fence Mesh
DINGZHOU TIAN YILONG METAL PRODUCTS CO., LTD. , https://www.wiremeshsolution.com