The research and development of tissue engineering scaffold material is the core element of tissue engineering development and application. Zein three-dimensional porous bionic scaffold material is a new natural scaffold material made from the main storage protein in corn. Because it has good biocompatibility and biodegradability, and has better mechanical properties than all other natural polymer scaffolds, it has great development and application prospects.
Tu Jinwen, Master of the Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine, Chinese Academy of Sciences, Master Tu, etc., under the guidance of mentor Zhang Xiaoling, associate researcher and subject leader Dai Kerong, in collaboration with Professor Wang Jinye, Shanghai Institute of Organic Chemistry, will Bone marrow mesenchymal stem cells were seeded on zein scaffold material to achieve effective proliferation and osteogenic differentiation of stem cells. The ectopic osteogenesis model in nude mice and the model of large radius bone defect in rabbits were successfully constructed in vivo to further validate this cell material complex The in vivo osteogenic potential confirms that the cell material complex with biological activity and osteogenic differentiation potential exhibits good biocompatibility, osteogenic activity, biodegradability, and angiogenic activity in the in vivo animal model. He successfully induced ectopic osteogenesis and effectively treated large bone defects. The results of this study suggest that zein scaffold materials are very likely to be used as a new type of natural organic materials in bone tissue engineering.
The results of this study were published online in the 2009 Biomaterials magazine. The work was supported by the National Basic Science Research Program (973 Project), the National Natural Science Foundation of China, the Shanghai Youth Science and Technology Star Project and Shanghai Surgery Plant Key Experiment Room project support.
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