Guide
Gene sequencing is getting closer and closer to ordinary people. And this is getting closer and closer, which will ultimately improve the quality of life for everyone.
Gene sequencing: it is important anyway
Why do you want to sequence genes? Because you have to figure out what is going on in our body, and why?
Only by understanding these can we implement more accurate and effective treatment, that is, precision medicine. Therefore, gene sequencing is an important part of precision medicine, and precision medicine is the direction of future medical development. This has basically become a public opinion, so it will be incorporated into the national strategy by the US and medium countries.
Under this logic, it can basically be understood as the development of gene sequencing, which dominates the degree of implementation, precision and breadth of precision medicine.
In other words, what kind of quality health protection each of us can enjoy.
The development of gene sequencing, to be considered, includes the two dimensions of technology and business.
Why? It’s very simple. The best of technology development, can’t be practical, or can’t be used. Doesn’t it have anything to do with ordinary people?
Fortunately, in the gene sequencing industry, these two have been developed in recent years. It is a steady walk with two legs.
First at the technical level. In recent years, the rapid development of sequencing technology, scientists continue to deepen their understanding of the genome, and clinicians have paid more attention to the auxiliary role of gene sequencing in the diagnosis and treatment of diseases. From the clinical point of view, it provides a case and application for technical application and research.
Gene sequencing: technology is developing
2000 can be said to be the watershed of sequencing technology. It was formerly the Sanger generation sequencing technology, followed by the second generation sequencing technology (NGS). After 2010, the development of three generations of sequencing technology entered the people's field of vision. Among them, the development of NGS has advanced by leaps and bounds, and the sequencing technology has been continuously optimized, and the throughput and speed have been continuously improved.
With the use of more and more advanced sequencers as tools, scientists have greatly expanded their understanding of the genome.
Now high-throughput sequencers will advance the era of whole-genome sequencing, and scientists can perform comparative analysis of all-genetic information without bias. However, most of the research results of these researches are still “susceptible genes†rather than clinical pathogenic genes.
And since there are too many relevant professional discourses, it will not be launched here. What everyone needs to know is that as tools and technologies improve and the efficiency of researchers increases, so are the scientific papers and research on genomes.
I believe that at the current rate of development, the distance from genotype to phenotype will not be too far.
From genes to proteins, to physiological functions, and finally to phenotypes, we will be infinitely close to the code of life, and ultimately grasp the ultimate meaning of life and death.
On the other hand, technological advances have brought the biggest dividends and reduced costs.
Gene sequencing: business is following up
Technological advances reduce costs, which is at the heart of Moore's Law.
After 2008, the decline in sequencing costs directly broke Moore's Law, and people are on the way to the $100 genome sequencing.
Cost reductions are good for commercialization and the industry as low costs can lead to new business models, such as the consumer genomics market.
And low cost means that more people can enjoy the huge and decisive maintenance of this new technology.
The more people use it, the more they will expand this market, and the gains in the market will eventually feed back on technology research and push the lower limit of the industry's capabilities.
Yes, in this emerging genetic sequencing industry, there is such a virtuous circle that is being established.
The market value of gene sequencing, according to BBCRESERCH, increased from US$794 million in 2007 to US$4.5 billion in 2013, and is expected to maintain rapid growth in the next few years, reaching US$11.7 billion in 2018.
It seems that this will be a very profitable industry, right?
Gene sequencing: multiple efforts of participants
The rules of the market are very simple. If you are new and making money, the capital will vote with your feet.
Whether it is intellectual capital or financial capital.
Moreover, there is strong support from relevant national policies.
Therefore, precision medicine, which is based on gene sequencing, and the big creatures and big health industries behind it, have ushered in a flourishing spring. Hot money is surging and fighting spirits are high.
According to incomplete statistics, as of now, there are hundreds of gene sequencing service companies in China, mainly in Beijing, Shanghai, Guangzhou, Shenzhen, Hangzhou, Tianjin, Wuhan and other provinces and cities. In the most promising 2015, almost every week there was news of a new company.
In addition to those companies that have sniffed development opportunities and entered the industry halfway through the industry, most of the industry companies with status and achievements have accumulated a lot of money.
Because of the technical barriers of gene sequencing and related industrial chains, it is not a matter of buying advanced equipment and recruiting technical talents. It is almost impossible to make a difference in this field and even lead the future without completing enough research accumulation.
Therefore, the gene sequencing enterprises currently located in the first phalanx in China are basically deep-rooted for many years and have rich technical research reserves.
Among the four institutions, apart from the late establishment of Berry and Kang, Huada Gene, Daan Gene and Boao Bio were established around 2000 and have accumulated for more than ten years. Even Berry and Kang, which were established in 2010, are actually one of the pioneers of the next generation of sequencing technology in the world, and they have enough technical resources to be among the best.
This industry is not destined to be a simple business. Only the combination of production and research, or even the combination of production, education and research can achieve sufficient results.
Fortunately, in addition to the fast-growing giants, some second-tier companies that seem inconspicuous in the national arena but have regional advantages are also catching up with the queue in their own way.
For example, from the Shaanxi-based gene.
Like most gene companies gathered in developed areas such as North, Shanghai, Guangzhou, Shenzhen and Zhejiang, the 佰美 gene rooted in the west started in 2001. From the beginning of its establishment, it explored a “production, study and research†with Northwest University. At the same time, with the convenience of Shaanxi scientific research and education highland, it has gathered a group of overseas returning industry elites, and is committed to the basic research and application transformation of pharmacogenomics and individualized medicine.
Therefore, before 2015, the company's genes have been hiding in the deep lanes like wine, and almost no attempt to enter the commercial field on a large scale.
But in the past 16 years, it has obviously not been vain.
It has obtained the qualifications of medical examination, forensic forensic identification and food testing, and has accumulated more than 100,000 samples and data of precision drug detection, providing testing services for more than 100 medical and inspection institutions nationwide.
In 2016, perhaps it is enough to prepare for all aspects, and the genes are starting to work. The company entered the market in a big way and comprehensively carried out various services in the field of genetic testing. It has successively become the Shaanxi Precision Medicine Genetic Testing and Demonstration Center and the Shaanxi Precision Medicine Genetic Testing Engineering Research Center, and successfully landed on the New Third Board and sounded the listing clock.
In fact, behind the success of the company's genes, there is also a "secret." In the second year of its establishment, the company jointly established the National Micro-Detection System Engineering Technology Research Center with Northwest University, and was approved by the Ministry of Science and Technology. It is currently one of the three major genetic testing engineering technology centers in China.
The development of the times, technological progress, and policy support have given the company such as Amami Gene a leap forward. And those genetic companies that specialize in each other are also working in different ways.
The growth and development of each of them has in fact formed a synergy that promotes the progress and fission of the entire genetic sequencing industry. This is a boon for anyone who suffers from a serious illness or a congenital hidden danger.
The arrogance of this kind of industry brings about objective and benign competition. Not only has it promoted technological advances, it has also steadily reduced costs.
Their scrambling is pushing genetic sequencing closer and closer to everyone.
As China's business environment and capital environment become more mature, the distance from science to business will become shorter and shorter, and the cost will be lower and lower. It is believed that gene sequencing will soon become a medical treatment that everyone can't live without.
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