"Key DNA damage response protein" 53BP1 works by binding to chromatin at a double-strand break point. Previous studies have shown that 53BP1 plays a role after an "ubiquitination" event promoted by RNF168, although its absorption into the breakpoint was thought to depend solely on the methylation of histone H4K20. Daniel Durocher and colleagues have now discovered that the absorption of 53BP1 involves the recognition of the "ubiquitination" of H4K20me2 and histone H2AK15. The "ubiquitin" mark and the surrounding environment of H2A were read by an area of ​​53BP1 that they called "the subject of absorption depending on ubiquitination".
Beijing Jiehui Biotechnology Co., Ltd. is established on the basis of the State Key Laboratory. It is a high-tech enterprise co-founded by senior personnel with backgrounds in life sciences, biotechnology, and returned overseas students.
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