Recently, a new study by Danish researchers described a new mechanism used by cells to communicate with each other. This breakthrough discovery can improve people's understanding of cell surface cilia and help people further understand related diseases and birth defects.
Cilia on cell surface
Primary cilia (Primarycilia) is a surface protrusion structure that almost all cells in the body have. These structures are responsible for receiving signals from other cells (such as growth factors and hormones) and converting these signals into intracellular responses. If the fibrils are defective, it will cause a series of serious diseases, including heart disease, polycystic kidney disease, blindness, cancer, obesity and diabetes. However, previously people did not understand the specific mechanism of fibrillar capture and conversion of signals.
"We found that fibrillars can not only capture signals through the receptors on the top, but also transport specific receptors to the bottom of the fibrillar. When these receptors reach the bottom of the fibrillar, they activate and interact with some other signaling systems. Transforming growth factor TGFβ receptor belongs to this type of receptor. Previous studies have shown that TGFβ receptor is involved in some birth defects and cancer. It can be said that the bottom of the fibrillar is a control center, which is ensured by regulating cell functions. Fetus development and maintenance of adult organ function. "
TGFβ signal and heart development
Professor Lars Allan Larsen has many years of experience in cardiac development research. He added: "TGFβ signaling is very important in the development of the heart. If there is a problem with this signal, it will cause congenital heart disease. According to statistics, about 1% of newborns are affected by this disease. And Our achievement is an important step in analyzing the pathogenesis of congenital heart disease. "The researchers also pointed out that TGFβ signaling is also associated with a variety of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and mental retardation Wait.
Fibrils are important for human health, and scientists have always been interested in this structure. In the next step, the researchers will analyze the regulation of TGFβ signaling by fibrils in some specific biological processes. They have begun to study the mechanism of action of fibrils when stem cells differentiate into nerve cells.
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